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Case Study: Hemolytic Uremic Syndrome

By Santa J. Bartholomew M.D. FAAP, FCCM

See Corresponding Journal Article: Hemolytic Uremic Syndrome (HUS)

A 7-year-old boy presented to the emergency department with concerns of bloody diarrhea.  His mother states he was at a Boy Scout retreat approximately 2 days ago.  The child came home lethargic, however mom felt this was related to the long weekend and allowed the boy extra sleep.  The next morning, the child awoke late in the morning around 11 AM and ate a small breakfast.  Approximately 30 minutes later, he had an episode of vomiting and diarrhea.  Again, the mother was not overly concerned as he seemed otherwise okay and the child took an afternoon nap.  He then woke up and had 3 episodes of severe bloody diarrhea.  She presented to the emergency department for further evaluation and management.

Upon evaluation by the emergency department provider, the boy appeared fatigued and dehydrated.  An IV was started and appropriate fluid resuscitation was provided.  His vital signs were relatively stable.  His heart rate was mildly increased at 115 bpm.  His blood pressure was normal at 101/56.  His respiratory rate was normal, and his oxygen saturation was also normal.  He was discharged home after signs he had improved.  They were advised to obtain a stool sample at home and return to their primary care provider for further management and recommendations.  Laboratory work was not obtained.

At approximately 5 AM, the mother represented to the emergency department as the child symptoms had worsened.  He now had developed severe abdominal pain, fever of 101.2, along with uncontrollable bloody diarrhea, and the child was severely pale.  Laboratory work was obtained, indicating a hemoglobin of 5.3, platelet count of 55, WBCs 28, and abnormal liver enzymes.  He also had abnormal electrolytes including a sodium of 135, potassium of 3.6, and bicarb of 20.  Creatinine was 2.3 and BUN elevated at 22. His urinalysis was grossly positive for infection and later culture positive for E. coli.  A stool culture was brought in by mom also testing positive for E. coli.  The child was again given proper fluid resuscitation and immediately admitted to the pediatric intensive care unit.  Consult specialists included a pediatric nephrologist.  The child spent 2 weeks in the intensive care unit and required continuous renal replacement therapy (dialysis).  His laboratory work was monitored closely and he was required to continue his dialysis intermittently at home.  After intense investigation, it was noted the child consumed undercooked meat during his Boy Scout adventures and this was the likely culprit contributing to his diagnosis of HUS.


Hemolytic uremic syndrome (HUS) is clinically defined as a triad including hemolytic anemia, thrombocytopenia, and acute kidney injury.  This condition causes abnormal vessel wall and microvascular thrombosis (clotting) of the red blood cells.  This causes destruction of blood platelets, thereby causing a low red blood cell count and ultimately acute kidney failure.  This is a complex renal condition-affecting children typically under the age of 5.  Some children recover from the disorder, however it is oftentimes fatal and if the child survives, 50% of the cases require short-term kidney replacement therapy.


HUS was previously defined as typical, primarily including the E. coli infection Shigella Toxin.  Atypical HUS was caused by other factors.  Ongoing medical research has given us a better and understanding of pathophysiological pathways.  The condition is now classified as hereditary, and acquired HUS.  The focus of this paper will be on acquired HUS as this is more common.  Hereditary HUS is of course caused by gene mutations including coagulation pathways.  Acquired HUS includes a more primary typical infection including Shiga toxin-producing E. coli (STEC), accounting for 90% of cases, and Streptococcus pneumoniae.  Pneumococcal associated HUS typically affects infants and younger children and remains at less than 0.5%.  These patients also present with pneumonia versus the common diarrheal episodes.


The causes of HUS is typically E. coli bacterial infection crossing into the intestines and thereby entering the bloodstream.  Tiny blood vessels are damaged during this process “clogging” tiny vessels in the kidney, damaging the body’s filtering system and thereby causing acute kidney failure.  Typically, the culprit is undercooked or spoiled food.  Another commonality is thawing meats, dripping onto other food contaminated in the refrigerator or during the processing of preparing meat.  Exposure to contaminated water can also be a factor.


HUS is commonly diagnosed by the standard triad below:

  • Hemolytic anemia- diagnosed by hemoglobin of less than 8 g/dl.
  • Thrombocytopenia- characterized by a platelet count of less than 140,000.
  • Acute kidney injury-diagnosed by elevated serum creatinine along with elevated BUN levels and low urine output. Hematuria and proteinuria may also occur. 


HUS is managed with supportive treatment, including fluid volume replacement therapies with IV fluids and IV nutritional supplementation.  Adequate nutrition, reduction of nephrotoxic drugs, appropriated therapy, and of course fluid and electrolyte management.  Blood transfusions and/or platelet transfusions are also warranted.  The body is volume depleted and blood transfusions help the body fight this infection.  Approximately 50% of cases require dialysis.  Typically in the pediatric intensive care units continuous renal replacement therapy is performed by a pediatric intensivist along with a pediatric nephrologist.  If the kidney function does not fully recover this is required at home as well.  Children that do fully recover require ongoing follow-up and management by a pediatric nephrologist.  The damage to the kidneys is so acute and harmful, they can later develop proteinuria or hypertension issues, resulting in chronic kidney disease at an early age.


HUS is a very complex disorder and can be extremely disruptive to a child’s psychological health as well.  These children typically stay several weeks in the pediatric intensive care unit and are managed by a multidisciplinary team.  Unfortunately, not every child survives this complex disease, however today since there are more medical resources and developments nearly 85% of children survive this disorder.  Prompt evaluation and experience of the medical field is necessary to ensure survival.


Gülhan, B., & Özaltın, F. (2021, September). Hemolytic uremic syndrome in children. Turkish archives of pediatrics.

The Children’s Hospital of Philadelphia. (2014b, August 24). Hemolytic uremic syndrome in children. Children’s Hospital of Philadelphia.

Hemolytic uremic syndrome (HUS). National Kidney Foundation. (2022, January 3).

Overview of hemolytic uremic syndrome in children. UpToDate. (n.d.-b).

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Santa J. Bartholomew, MD, FAAP, FCCM

Award-winning Pediatrician with more than 35 years of clinical experience. She has been performing legal review and court services since 1993.
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